Can Multi-stage approval be set up?

Yes, that can be done. You can choose to set up a hierarchical approval where the expense report will be submitted and approved based on the reporting hierarchy of the company. The hierarchical approval is configured when you invite a user to Zoho Expense.

Else, you can create custom approvals where the approval flow would be based on the criteria you select.

To select the approval flow type, go to Admin > Settings > Reports. Select the approval type that works well with your company and hit Save.